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IGF-1 LR3 · 1 MG | Factor de Crecimiento - Análogo de Larga Duración

Product Details

  • Technical Name: IGF-1 LR3 1 mg, Polvo Liofilizado para Investigación
  • Laboratory / Brand: Syntex Labs
  • Active Ingredient (INN): IGF-1 LR3 - Factor de Crecimiento similar a la Insulina
  • Pharmaceutical Form: Polvo Liofilizado para Solución Inyectable
  • Concentration: 1 mg/vial
  • CAS Number: 946841-12-7
  • Internal SKU: SKU-IGF1LR3-1MG-946841127
Syntex Labs IGF-1 LR3 - Factor de Crecimiento similar a la Insulina Polvo Liofilizado para Solución Inyectable CAS: 946841-12-7
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IGF-1 LR3 · 1 MG | Factor de Crecimiento - Análogo de Larga Duración

Upgraded Formula Muscle Growth Recovery

10 Servings Per Container: US$10.00 / serving

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US$99.99 USD
In stock (10,000 piece)
IGF-1 LR3 is a modified synthetic peptide of 83 amino acids that acts as a potent IGF-1 receptor agonist, promoting protein synthesis, muscle hypertrophy, and recovery. Laboratory-grade with ≥99% purity by HPLC-MS. Each vial contains 1 mg of IGF-1 LR3 as sterile lyophilized powder, designed for in vitro scientific research and animal models. Manufactured under strict GMP standards, with full lot traceability and certificate of analysis available. SKU: SKU-IGF1LR3-1MG. CAS: 946841-12-7. Store at 2-8°C in a dry place protected from light.

IGF-1 LR3 (Long-Arginine 3 Insulin-like Growth Factor-1) is a modified synthetic peptide designed to mimic and enhance the effects of endogenous IGF-1. Its structure has been altered to resist binding to carrier proteins (IGF-BPs), which significantly prolongs its half-life and enhances its bioavailability in muscle tissue.

What sets IGF-1 LR3 apart from other IGF-1 variants is its long-acting action and high anabolic potency. Unlike natural IGF-1, which rapidly binds to carrier proteins and degrades, IGF-1 LR3 remains active for a longer period, allowing sustained stimulation of protein synthesis and greater nutrient uptake by muscle cells.

Scientific Rationale

The efficacy of IGF-1 LR3 is supported by research in the fields of molecular biology and skeletal muscle physiology.

Muscle Protein Synthesis: IGF-1 LR3 activates the PI3K/Akt/mTOR signaling pathway, which directly stimulates the synthesis of new contractile proteins. This translates into an increase in lean muscle mass and an improvement in muscle fiber density.

Nutrient Uptake: It improves the transport of glucose and amino acids into the muscle cell, optimizing nutrient utilization for repair and growth.

Cell Proliferation and Differentiation: It promotes the activation of satellite cells, favoring the formation of new muscle fibers (hyperplasia) and the repair of damaged tissue following intense exercise.

Anti-Apoptotic Effect: It helps prevent programmed cell death in muscle tissue, preserving muscle mass even during periods of high metabolic stress.

Improved Recovery: By accelerating cellular regeneration, it reduces muscle soreness and recovery times between training sessions.

What This Means for the Athlete

IGF-1 LR3 offers a direct and potent approach to optimizing performance and body composition:

Accelerated Muscle Growth: Increased protein synthesis and hyperplasia allow for faster and more efficient muscle development.

Enhanced Recovery: Accelerated muscle tissue repair means fewer forced rest days and greater frequency of quality training.

Better Nutrient Use: Greater amino acid and glucose uptake ensures that every meal is maximally utilized for tissue building.

Greater Muscle Density: Promotes the development of denser and stronger muscle fibers, improving strength and definition.

Muscle Preservation: Helps maintain lean mass even during phases of caloric deficit or high-intensity training.

Pairing Strategy: IGF-1 LR3 + MGF

IGF-1 LR3 and MGF (Mechano Growth Factor) are often used together for a comprehensive muscle development protocol. While MGF acts locally after muscle damage to initiate satellite cell activation and initial repair, IGF-1 LR3 provides a systemic and prolonged anabolic stimulus that amplifies and extends muscle growth. Together, they address both the early repair phase and sustained growth—a powerful combination for those seeking maximum muscle gain.

WHY CHOOSE IGF-1 LR3?
Potent and sustained anabolic effect
Extended half-life (fewer injections)
Accelerates post-workout recovery
Improves nutrient utilization
Promotes both hyperplasia and hypertrophy

1. PRIMARY BENEFIT

Accelerated Muscle Growth

IGF-1 LR3 is a potent analog of Insulin-like Growth Factor that amplifies anabolic processes to build lean muscle mass faster and more efficiently.

2. HOW DOES IT WORK?

Long-Acting Action: Its modified structure gives it a 20-30 hour half-life—much longer than natural IGF-1.

Protein Synthesis: Activates the mTOR pathway to stimulate new muscle protein creation.

Nutrient Uptake: Improves amino acid and glucose transport into muscle cells.

Hyperplasia: Promotes the formation of new muscle fibers.
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IGF-1 LR3 · 1 MG | Factor de Crecimiento - Análogo de Larga Duración

IGF-1 LR3: El Análogo de Larga Duración para la Máxima Hipertrofia y Recuperación

Para el atleta que busca llevar su desarrollo muscular al siguiente nivel, IGF-1 LR3 representa una herramienta revolucionaria en la investigación del crecimiento muscular. Este análogo de larga duración del Factor de Crecimiento Similar a la Insulina (IGF-1) ha sido diseñado para resistir la unión a proteínas transportadoras, prolongando su vida media y potenciando su biodisponibilidad en el tejido muscular.

Beneficio Principal: Soporte Máximo para el Crecimiento Muscular y la Recuperación

IGF-1 LR3 activa la vía de señalización PI3K/Akt/mTOR, estimulando directamente la síntesis de nuevas proteínas contráctiles y promoviendo la hipertrofia muscular. Su estructura modificada le confiere una estabilidad y una vida media prolongada, permitiendo una acción sostenida que maximiza los resultados en los protocolos de investigación. Esto se traduce en:

Aumento significativo de la masa muscular magra.

Mejora de la densidad y el tamaño de las fibras musculares.

Aceleración de la recuperación post-entrenamiento.

Evidencia Científica de Eficacia

La eficacia de IGF-1 LR3 está respaldada por investigaciones en el campo de la biología molecular y la fisiología del músculo esquelético. Los estudios han demostrado que IGF-1 LR3:

Estimula la síntesis de proteínas musculares: A través de la activación de la vía PI3K/Akt/mTOR, promoviendo el crecimiento y la reparación muscular.

Mejora la captación de nutrientes: Optimizando el transporte de glucosa y aminoácidos hacia el interior de la célula muscular.

Promueve la proliferación y diferenciación celular: Activando células satélite y favoreciendo la formación de nuevas fibras musculares.

Impacto en el Rendimiento Deportivo

IGF-1 LR3 es una herramienta invaluable para atletas de alto rendimiento, culturistas y cualquier persona que busque optimizar su composición corporal. Sus efectos incluyen:

Aumento de la fuerza y la potencia muscular.

Reducción del tiempo de recuperación entre entrenamientos.

Mejora de la composición corporal, con un aumento de la masa magra y una reducción de la grasa.

Estrategia de Combinación: IGF-1 LR3 + MGF

La combinación de IGF-1 LR3 con MGF (Mecanofactor de Crecimiento) representa una estrategia avanzada para optimizar el crecimiento muscular. Mientras que MGF actúa en las fases iniciales de la reparación muscular, promoviendo la activación de células satélite, IGF-1 LR3 actúa en las fases posteriores, promoviendo la diferenciación y la síntesis de proteínas. Esta combinación permite un enfoque integral para el crecimiento muscular, abarcando tanto la proliferación celular como la hipertrofia.

Key Benefits of IGF-1 LR3 Potent Stimulation of Muscle Protein Synthesis IGF-1 LR3 activates the PI3K/Akt/mTOR signaling pathway, which is fundamental for muscle protein synthesis and cell growth. This pathway promotes mRNA translation and formation of new contractile proteins, resulting in increased lean muscle mass and improved muscle fiber density. mTOR activation also inhibits autophagy and protein degradation, creating a sustained anabolic environment that favors long-term muscle growth. Satellite Cell Proliferation and Differentiation IGF-1 LR3 promotes satellite cell activation, the muscle stem cells responsible for repair and muscle growth. By stimulating proliferation and differentiation of these cells, IGF-1 LR3 favors new muscle fiber formation (hyperplasia) and repair of damaged tissue after intense exercise. This effect is especially important for injury recovery and adaptation to high-intensity training. Improved Nutrient Uptake and Glucose Utilization IGF-1 LR3 improves glucose and amino acid transport into muscle cells, optimizing nutrient use for repair and growth. By increasing GLUT4 transporter translocation to the cell membrane, IGF-1 LR3 facilitates glucose entry into muscle, improving energy availability for training and recovery. This effect is especially valuable in bulking cycles where caloric and protein intake is elevated. Accelerated Post-Workout Recovery IGF-1 LR3 promotes regeneration of damaged muscle tissue after intense exercise, accelerating recovery and reducing downtime. By stimulating collagen synthesis and fibroblast proliferation, IGF-1 LR3 also improves tendon and ligament repair, reducing injury risk and allowing more frequent and intense training. Increased Muscle Fiber Density and Size IGF-1 LR3 promotes both hypertrophy (increased size of existing fibers) and hyperplasia (formation of new muscle fibers), resulting in significant increases in muscle mass and strength. This effect is especially pronounced when combined with resistance training and adequate protein intake, potentiating the anabolic response to exercise stimulus. Improved Body Composition and Lean Mass/Fat Ratio IGF-1 LR3's anabolic action translates to significant improvement in body composition, with increased lean muscle mass and reduced body fat. By promoting nutrient utilization for muscle growth, IGF-1 LR3 reduces fat storage and favors a more defined and athletic physique.
Function and Mechanism of Action of IGF-1 LR3 IGF-1 LR3 (Long-Arginine3-IGF-1) is a modified synthetic 83-amino acid peptide that acts as a potent agonist of the IGF-1 receptor. Its structure has been altered by adding a 13-amino acid N-terminal extension (Met-Phe-Pro-Ala-Met-Pro-Leu-Ser-Leu-Leu-Leu-Leu-Leu) and substituting arginine at position 3 with glutamic acid, conferring greater stability and a prolonged half-life. Detailed Mechanism of Action: IGF-1 Receptor Binding: IGF-1 LR3 specifically and with high affinity binds to the IGF-1 receptor (IGF-1R) on the surface of target cells, including skeletal muscle, adipose tissue, and cartilage. This binding activates the receptor, which is a tyrosine kinase receptor, and triggers an intracellular signaling cascade. PI3K/Akt/mTOR Signaling Pathway Activation: IGF-1 LR3 binding to IGF-1R activates phosphatidylinositol-3-kinase (PI3K), which in turn activates protein kinase B (Akt). Akt phosphorylates and activates the mTORC1 complex (mammalian target of rapamycin), which is a central regulator of protein synthesis and cell growth. mTORC1 promotes mRNA translation and formation of new contractile proteins. Ras/MAPK Signaling Pathway Activation: IGF-1 LR3 binding to IGF-1R also activates the Ras/MAPK signaling pathway, which is involved in cell proliferation and differentiation. This pathway promotes expression of genes involved in cell growth and survival. Protein Synthesis Stimulation: PI3K/Akt/mTOR pathway activation leads to increased muscle protein synthesis, including contractile proteins (actin and myosin), resulting in increased muscle fiber size (hypertrophy). Cell Proliferation and Differentiation Promotion: IGF-1 LR3 promotes satellite cell proliferation and differentiation, the muscle stem cells, favoring new muscle fiber formation (hyperplasia) and damaged tissue repair. Improved Nutrient Uptake: IGF-1 LR3 improves glucose and amino acid transport into muscle cells, optimizing nutrient use for repair and growth.
How to Use IGF-1 LR3 Route of Administration: Injectable via subcutaneous (SC) or intramuscular (IM). Subcutaneous administration is the most common and preferred, as it allows gradual and constant absorption. Injection sites should be rotated (abdomen, thigh, gluteal region). Reconstitution: The product is presented as a lyophilized powder in a sterile vial. It must be reconstituted with bacteriostatic water for injection (or sterile water for injection) before use. Add the diluent slowly, gently swirling the vial to dissolve the powder. Do not shake vigorously. Research Protocol: Dosage and frequency must be determined by the researcher according to protocol goals. Common research protocols for IGF-1 LR3 use doses of 20-80 µg per administration, administered 1-2 times daily (typically post-workout). Research cycles of 4 to 8 weeks are recommended to assess changes in body composition and recovery. Storage: The lyophilized powder should be stored in a cool, dry place, protected from light and at controlled temperature (2-8°C). Once reconstituted, it must be refrigerated (2-8°C) and used within 30 days. Important Notice: Product intended EXCLUSIVELY FOR SCIENTIFIC RESEARCH in vitro and in animal models. Not approved for human use without prescription.
ACTIVE INGREDIENT IGF-1 LR3 (Long-Arginine 3 Insulin-like Growth Factor-1) Nature: Synthetic analog of human IGF-1 produced via recombinant DNA technology. Structure: 83-amino-acid polypeptide with structural modifications that extend its half-life. Molecular Weight: ~9.1 kDa Purity: >95% (verified by HPLC and SDS-PAGE) Function: Primary anabolic agent; stimulates protein synthesis, nutrient uptake, and muscle recovery. 2. EXCIPIENTS (STABILIZERS AND PROTECTANTS) Mannitol — Sugar alcohol acting as a cryoprotectant during lyophilization, preserving peptide structure. Trehalose — Sugar that stabilizes proteins and prevents degradation and aggregation. Tween 80 (Polysorbate 80) — Surfactant agent that prevents peptide molecule aggregation. BSA (Bovine Serum Albumin) or HSA (Human Serum Albumin) — Optional; protein that helps preserve long-term peptide activity. Buffer Solution — Typically PBS (Phosphate-Buffered Saline) or PB (Phosphate Buffer), which maintains pH and stability. 3. IMPORTANT WARNING Research use only.
Onset Time & Expected Results of IGF-1 LR3 Onset of Action (Immediate to Hours): IGF-1 LR3 begins acting almost immediately after administration, with a prolonged half-life allowing sustained action. PI3K/Akt/mTOR pathway activation and protein synthesis stimulation occur within the first hours after administration. Measurable Benefits (2-4 Weeks): Increased post-workout recovery and perception of greater training capacity are typically the first observable effects. Body composition begins to improve in this period, with increased muscle mass and fat reduction. Full Effect (8-12 Weeks): For significant changes in body composition and muscle hypertrophy, the full effect often requires 8-12 weeks of consistent use according to the research protocol. Factors Influencing Results: The speed and magnitude of results depend on dose administered, injection frequency, subject's nutritional status, and adherence to the research protocol.
Clinical Research & 3rd Party Test Results of IGF-1 LR3 Scientific evidence on IGF-1 LR3 is supported by preclinical and clinical studies demonstrating its efficacy as an anabolic agent and its safety in research populations. Scientific Evidence: Animal Model Studies: IGF-1 LR3 has demonstrated significant increases in muscle mass and strength in animal models, with reduction in body fat. Muscle Cell Studies: IGF-1 LR3 has demonstrated stimulation of protein synthesis and satellite cell proliferation in muscle cell cultures. Safety Profile: IGF-1 LR3 has a favorable safety profile in preclinical studies, with minimal side effects at therapeutic doses. Research Applications: IGF-1 LR3 is used in research on muscle hypertrophy, injury recovery, sarcopenia, and body composition. Syntex Labs Quality Standards: Lab Grade: Purity ≥99% by HPLC-MS. QR Tracking: Complete batch traceability. Secure Batch Label: "Scratch to See" security system. 3rd Party Results: Access to Certificates of Analysis (COA) from accredited external laboratories.

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