CITRATO DE CLOMIFENO · 20 MG · 100 TABLETAS | Restauración Hormonal. Recuperación Inteligente.

Key Benefits of Clomifene Citrate Restoration of Natural Testosterone Production Clomifene citrate blocks estrogen receptors in the hypothalamus, tricking the body into thinking estrogen levels are low . As a result, the pituitary secretes more LH and FSH, which stimulate the testes to produce more testosterone . A 2025 systematic review and meta-analysis demonstrated that SERM therapy significantly improved total testosterone levels by a mean of 273.76 ng/dL compared to placebo . Effective Post-Cycle Therapy (PCT) Clomifene citrate is one of the most common and effective drugs used in PCT protocols . It helps counteract the effects of hormonal suppression after an anabolic steroid or SARM cycle, minimizing muscle mass loss, restoring energy and libido . Typical PCT dosing is 25-50 mg per day for 4-6 weeks . Male Fertility Stimulation Clomifene citrate has been traditionally used to induce ovulation in women and can also improve male fertility by increasing LH and FSH production, which in turn stimulates sperm production in the testes . Alternative to Testosterone Therapy SERM therapy in men with functional hypogonadism can be considered an alternative to testosterone gel therapy. No significant differences in total testosterone levels were observed between the SERM group and the testosterone gel group in the 2025 systematic review and meta-analysis . Effect on LH and FSH Clomifene citrate significantly increases LH and FSH levels in hypogonadal men. The 2025 systematic review and meta-analysis demonstrated improvements in LH (MD: 4.66 IU/L) and FSH (MD: 4.59 IU/L) compared to placebo . Prevention of Estrogenic Side Effects By blocking estrogen receptors, clomifene citrate can help mitigate some of the estrogenic side effects that may occur during or after a steroid cycle

Function and Mechanism of Action of Clomifene Citrate Clomifene citrate is a non-steroidal selective estrogen receptor modulator (SERM) that acts as an estrogen agonist/antagonist . It was the first SERM to be synthesized and has been used since the early 1960s for ovulation induction . Detailed Mechanism of Action: Estrogen Receptor Binding: Clomifene citrate binds to estrogen receptors (ERα and ERβ) in the hypothalamus and pituitary, causing conformational changes that facilitate interactions with coactivator or corepressor proteins . SERM activity is intrinsic to each ligand, achieving its unique profile through specific interactions in the target cell . Negative Feedback Blockade: By binding to estrogen receptors, clomifene inhibits the binding of endogenous estrogens, abolishing the normal inhibition (negative feedback) that estrogen exerts on the synthesis and release of gonadotropins (LH and FSH) from the anterior pituitary . LH and FSH Stimulation: As a result of the negative feedback blockade, the pituitary secretes more LH and FSH to compensate for the perception of low estrogen levels . The increase in LH stimulates the testes to increase natural testosterone production . Tissue-Specific Effects: SERM activity is tissue-specific, meaning they can act as agonists in some tissues and as antagonists in others . Clomifene has predominantly antagonistic effects in the uterus, unlike tamoxifen which can act as a partial agonist . Comparison with Other SERMs: Clomifene and tamoxifen, the two oldest SERMs, have unique clinical activity profiles . Tamoxifen has ten times higher affinity for ERβ than clomifene, contributing to their different tissue effects . Clomifene has been the basis for the development of enclomifene, which is its active isomer.

How to Use Clomifene Citrate Route of Administration: Oral. Clomifene citrate is administered as tablets for oral ingestion. Tablets should be swallowed whole with water. Dosage: Dosage should be determined by a physician according to indications and patient condition. General dosage guidelines for clomifene citrate include: Post-Cycle Therapy (PCT): 25-50 mg per day for 4-6 weeks . Some protocols recommend starting with a higher dose (100 mg per day) during the first week and then tapering to 50 mg per day . Hypogonadism (Males): 12.5-50 mg per day, depending on response and tolerance . Ovulation Induction (Females): 50 mg per day for 5 days, starting on day 5 of the menstrual cycle . Frequency: Daily administration. Clomifene citrate has a long half-life, allowing for single daily administration. Treatment Duration: Depends on the type and intensity of symptoms. For PCT, cycles of 4-6 weeks are recommended . For hypogonadism treatment, duration may be longer and should be monitored by a physician. Storage: Store in a cool, dry place, protected from light and at controlled temperature (2-8°C). Keep out of reach of children. Important Notice: Product intended FOR HUMAN USE under medical supervision. Clomifene citrate is a prescription medication and its use must be supervised by a physician. Common side effects include vasomotor flushes (10.4%), abdominal discomfort (5.5%), nausea and vomiting (2.2%), and visual symptoms (1.5%) such as blurred vision or flashes . Serious side effects include transient visual events or irreversible vision loss, hypertriglyceridemia, pancreatitis, hepatitis, and ovarian cancer risks in cases of prolonged use . Not recommended in people with hepatic disease, undiagnosed visual disorders, or known hypersensitivity to clomifene. Clomifene citrate is contraindicated in pregnancy

Ingredients of Clomifene Citrate Active Ingredient: Clomifene Citrate: A non-steroidal selective estrogen receptor modulator (SERM) that acts as an estrogen agonist/antagonist . Used for hormonal function restoration and post-cycle therapy. Molecular formula: C₂₆H₂₈ClNO₈. Molecular weight: 598.04 g/mol. CAS: 50-41-9. Excipients: Each 20 mg tablet contains the following excipients (according to standard clomifene citrate formulations): Lactose monohydrate: Used as an excipient and bulking agent. Microcrystalline cellulose: Used as a bulking agent and disintegrant. Corn starch: Used as a disintegrant and bulking agent. Magnesium stearate: Used as a lubricant. Colloidal anhydrous silica: Used as a flow agent. Note: Specific excipients may vary by manufacturer. Consult the product leaflet for the complete list of excipients. Note for Users: This product is a pharmaceutical-grade medication manufactured under strict quality control standards (GMP) by Kinetix Pharma, in the Czech Republic. Each package contains 100 tablets of 20 mg each. Clomifene citrate is a prescription medication and its use must be supervised by a physician.

Onset Time &amp;amp;amp;amp; Expected Results of Clomifene Citrate Onset of Action (Days to Weeks): Clomifene citrate begins acting within the first days after oral administration. Effects on LH and FSH levels are observed within the first days of treatment. Onset of action is rapid due to its direct mechanism of action on estrogen receptors. Measurable Benefits (2-4 Weeks): The first measurable changes in testosterone levels begin to be visible within the first 2-4 weeks of consistent use. The 2025 systematic review and meta-analysis demonstrated that SERM therapy significantly improved total testosterone levels by a mean of 273.76 ng/dL . Full Effect (4-6 Weeks): For complete testosterone level restoration and hormonal recovery, the full effect requires 4-6 weeks of consistent use, which is the typical duration of a PCT cycle . Factors Influencing Results: The speed and magnitude of results depend on dose administered, adherence to the treatment protocol, the patient&amp;amp;amp;#039;s baseline condition (degree of hormonal suppression), and individual metabolism.

Clinical Research &amp;amp;amp;amp; 3rd Party Test Results of Clomifene Citrate Scientific evidence on clomifene citrate comes from decades of medical use, clinical studies, and a systematic review and meta-analysis published in 2025 . Clinical Evidence in Humans: Testosterone Restoration (2025 Meta-Analysis): A systematic review and meta-analysis of randomized controlled trials evaluated the efficacy and safety of SERMs (clomifene and enclomifene) in treating men with functional hypogonadism. SERM therapy significantly improved total testosterone (MD: 273.76 ng/dL), LH (MD: 4.66 IU/L), and FSH (MD: 4.59 IU/L) compared to placebo . No significant differences in total testosterone were observed between the SERM group and the testosterone gel group . Post-Cycle Therapy: Clomifene citrate is one of the most common and effective drugs used in PCT protocols . Typical PCT dosing is 25-50 mg per day for 4-6 weeks . Monitoring hormone levels through blood tests during and after PCT is recommended to assess recovery . Ovulation Induction: Clomifene citrate was the first SERM synthesized and has been used since the early 1960s for ovulation induction in women . Safety Considerations: Common Side Effects: Reported adverse events include ovarian enlargement (13.6%), vasomotor flushes (10.4%), abdominal discomfort (5.5%), nausea and vomiting (2.2%), and visual symptoms (1.5%) . Serious Side Effects: Transient visual symptoms or irreversible vision loss, hypertriglyceridemia, pancreatitis, hepatitis, and ovarian cancer risks in cases of prolonged use . Contraindications: Clomifene citrate is contraindicated in pregnancy and in patients with hepatic disease, undiagnosed visual disorders, or known hypersensitivity to clomifene . Kinetix Pharma Quality Standards: Pharmaceutical Grade: Pharmaceutical-grade medication for human use. Manufacturing: Manufactured in the Czech Republic under strict GMP standards by Kinetix Pharma. Quality Control: Each batch is subjected to quality control testing to ensure purity and potency.

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CITRATO DE CLOMIFENO · 20 MG · 100 TABLETAS | Restauración Hormonal. Recuperación Inteligente.

CITRATO DE CLOMIFENO · 20 MG · 100 TABLETAS | Restauración Hormonal. Recuperación Inteligente.

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